SIRT1 in Neurodevelopment and Brain Senescence
نویسندگان
چکیده
منابع مشابه
SIRT1 in Neurodevelopment and Brain Senescence
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals. These proteins also play an important role in maintaining neuronal health during aging. During neuronal development, the SIR2 ortholog SIRT1 is structurally important, promoting axonal elongation, neurite outgrowth, and dendritic branching...
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ژورنال
عنوان ژورنال: Neuron
سال: 2014
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2014.01.028